Gene name

Upk3a (Upk3,Upk3a_predicted)

Experiment(s)

For this entry:
UPK3A_HUMAN (Upk3a)
Species Homo sapiens
Localization Apical plasma membrane
Reference Višnjar T,Chesi G,Iacobacci S,Polishchuk E,Resnik N,Robenek H,Kreft M,Romih R,Polishchuk R,Kreft ME (2017) Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models., Sci Rep, 7, 12842.
[PubMed] [DOI]
Evidence level Fluorescent tagging
Organ Kidney
Cell MDCK cells (distal tubule)
Notes Part of the obligatory heterodimer UPKIb-UPKIIIa
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 19 Signal peptide
20 208 Extracellular
209 232 Membrane
233 287 Cytoplasmic
Phosphorylation
Glycosylation
Position Site resource Glycan resource PubMed link(s)
74 UniPep

Family and domain data

Database Domain/Family name
InterPro Uroplakin-3
InterPro Uroplakin-3a

Interactions

With (links to EBI) #Exp PubMed links
SGTA_HUMAN 3 25416956
SGTB_HUMAN 3 32296183
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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