Gene name
Trpc1 (TRP1,Trrp1)
Experiment(s)
For this entry:
TRPC1_HUMAN (Trpc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Bandyopadhyay BC,Swaim WD,Liu X,Redman RS,Patterson RL,Ambudkar IS (2005) Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx., J Biol Chem, 280, 12908-16. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A HA tag was used for imaging. Authors were silent about the clone source |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 350 | Cytoplasmic |
| 351 | 371 | Membrane |
| 372 | 386 | Extracellular |
| 387 | 407 | Membrane |
| 408 | 419 | Cytoplasmic |
| 420 | 439 | Membrane |
| 440 | 456 | Extracellular |
| 457 | 476 | Membrane |
| 477 | 496 | Cytoplasmic |
| 497 | 517 | Membrane |
| 518 | 539 | Extracellular |
| 540 | 559 | Membrane |
| 560 | 586 | Cytoplasmic |
| 587 | 607 | Membrane |
| 608 | 622 | Extracellular |
| 623 | 643 | Membrane |
| 644 | 793 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ankyrin_rpt |
| InterPro | Ankyrin_rpt-contain_sf |
| InterPro | Ion_trans_dom |
| InterPro | TRP_dom |
| InterPro | TRPC1_channel |
| InterPro | TRPC_channel |
| Pfam | Ion_trans |
| Pfam | TRP_2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| PKD2_HUMAN | 9 | 25114176 |
| TRPV4_MOUSE | 10 | 25114176 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.