Gene name
Scnn1b (ENAC)
Experiment(s)
For this entry:
SCNNB_HUMAN (Scnn1b)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Hanukoglu I,Boggula VR,Vaknine H,Sharma S,Kleyman T,Hanukoglu A (2017) Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages., Histochem Cell Biol, 147, 733-748. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Sweat glands |
| Cell | Ductal cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 49 | Cytoplasmic |
| 50 | 70 | Membrane |
| 71 | 527 | Extracellular |
| 528 | 553 | Membrane |
| 554 | 640 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 135 | N-GlycoSiteAtlas | 24190977 | |
| 449 | N-GlycoSiteAtlas | 24190977 | |
| 484 | N-GlycoSiteAtlas | 24190977 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ENaC |
| InterPro | ENaC_chordates |
| InterPro | ENaC_CS |
| Pfam | ASC |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| SCNNA_HUMAN | 2 | 21775436 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.