Gene name
SLC5A2 (Sglt2,ECO:0000303|PubMed:15489334})
Experiment(s)
For this entry:
SC5A2_MOUSE (SLC5A2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Jiang M,Wang Q,Karasawa T,Koo JW,Li H,Steyger PS (2014) Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides., PLoS One, 9, e108941. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 23 | Extracellular |
| 24 | 43 | Membrane |
| 44 | 61 | Cytoplasmic |
| 62 | 83 | Membrane |
| 84 | 97 | Extracellular |
| 98 | 116 | Membrane |
| 117 | 137 | Cytoplasmic |
| 138 | 157 | Membrane |
| 158 | 171 | Extracellular |
| 172 | 192 | Membrane |
| 193 | 199 | Cytoplasmic |
| 200 | 219 | Membrane |
| 220 | 271 | Extracellular |
| 272 | 290 | Membrane |
| 291 | 310 | Cytoplasmic |
| 311 | 332 | Membrane |
| 333 | 378 | Extracellular |
| 379 | 400 | Membrane |
| 401 | 420 | Cytoplasmic |
| 421 | 442 | Membrane |
| 443 | 453 | Extracellular |
| 454 | 475 | Membrane |
| 476 | 482 | Cytoplasmic |
| 483 | 503 | Membrane |
| 504 | 524 | Extracellular |
| 525 | 545 | Membrane |
| 546 | 649 | Cytoplasmic |
| 650 | 669 | Membrane |
| 670 | 670 | Extracellular |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Glc_symporter_sf |
| InterPro | Na/solute_symporter |
| InterPro | Na/solute_symporter_CS |
| Pfam | SSF |