Gene name
SLC29A2 (DER12,ENT2,HNP36)
Experiment(s)
For this entry:
S29A2_HUMAN (SLC29A2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Mangravite LM,Xiao G,Giacomini KM (2003) Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells., Am J Physiol Renal Physiol, 284, F902-10. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
S29A2_HUMAN (SLC29A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Klein DM,Evans KK,Hardwick RN,Dantzler WH,Wright SH,Cherrington NJ (2013) Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1., J Pharmacol Exp Ther, 346, 121-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 12 | Cytoplasmic |
| 13 | 33 | Membrane |
| 34 | 68 | Extracellular |
| 69 | 89 | Membrane |
| 90 | 98 | Cytoplasmic |
| 99 | 119 | Membrane |
| 120 | 126 | Extracellular |
| 127 | 147 | Membrane |
| 148 | 161 | Cytoplasmic |
| 162 | 183 | Membrane |
| 184 | 192 | Extracellular |
| 193 | 213 | Membrane |
| 214 | 289 | Cytoplasmic |
| 290 | 311 | Membrane |
| 312 | 326 | Extracellular |
| 327 | 344 | Membrane |
| 345 | 359 | Cytoplasmic |
| 360 | 380 | Membrane |
| 381 | 395 | Extracellular |
| 396 | 416 | Membrane |
| 417 | 431 | Cytoplasmic |
| 432 | 452 | Membrane |
| 453 | 456 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ENT1/ENT2 |
| InterPro | ENT2 |
| InterPro | Eqnu_transpt |
| InterPro | MFS_trans_sf |
| Pfam | Nucleoside_tran |