Gene name
SLC22A11 (OAT4)
Experiment(s)
For this entry:
S22AB_HUMAN (SLC22A11)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ekaratanawong S,Anzai N,Jutabha P,Miyazaki H,Noshiro R,Takeda M,Kanai Y,Sophasan S,Endou H (2004) Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules., J Pharmacol Sci, 94, 297-304. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22AB_HUMAN (SLC22A11)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Miyazaki H,Anzai N,Ekaratanawong S,Sakata T,Shin HJ,Jutabha P,Hirata T,He X,Nonoguchi H,Tomita K,Kanai Y,Endou H (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins., J Am Soc Nephrol, 16, 3498-506. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes | Apical localization was modulated by NHERF-family protein binding (through a PDZ motif) |
S22AB_HUMAN (SLC22A11)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ugele B,St-Pierre MV,Pihusch M,Bahn A,Hantschmann P (2003) Characterization and identification of steroid sulfate transporters of human placenta., Am J Physiol Endocrinol Metab, 284, E390-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
S22AB_HUMAN (SLC22A11)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Uehara I,Kimura T,Tanigaki S,Fukutomi T,Sakai K,Shinohara Y,Ichida K,Iwashita M,Sakurai H (2014) Paracellular route is the major urate transport pathway across the blood-placental barrier., Physiol Rep, 2, . [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 18 | Cytoplasmic |
| 19 | 38 | Membrane |
| 39 | 143 | Extracellular |
| 144 | 164 | Membrane |
| 165 | 171 | Cytoplasmic |
| 172 | 191 | Membrane |
| 192 | 198 | Extracellular |
| 199 | 219 | Membrane |
| 220 | 228 | Cytoplasmic |
| 229 | 249 | Membrane |
| 250 | 256 | Extracellular |
| 257 | 276 | Membrane |
| 277 | 344 | Cytoplasmic |
| 345 | 364 | Membrane |
| 365 | 374 | Extracellular |
| 375 | 396 | Membrane |
| 397 | 403 | Cytoplasmic |
| 404 | 423 | Membrane |
| 424 | 430 | Extracellular |
| 431 | 451 | Membrane |
| 452 | 463 | Cytoplasmic |
| 464 | 484 | Membrane |
| 485 | 491 | Extracellular |
| 492 | 512 | Membrane |
| 513 | 550 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 545 | 550 | Apical plasma membrane | PDZ-ligand |
Miyazaki H,Anzai N,Ekaratanawong S,Sakata T,Shin HJ,Jutabha P,Hirata T,He X,Nonoguchi H,Tomita K,Kanai Y,Endou H (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins., J Am Soc Nephrol, 16, 3498-506. [PubMed][DOI] |
Phosphorylation
| Position | Resource |
|---|---|
| 65 | 23145163 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| Pfam | Sugar_tr |