Gene name
SLC22A8 (OAT3,Roct)
Experiment(s)
For this entry:
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ljubojevic M,Herak-Kramberger CM,Hagos Y,Bahn A,Endou H,Burckhardt G,Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition., Am J Physiol Renal Physiol, 287, F124-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ljubojevic M,Herak-Kramberger CM,Hagos Y,Bahn A,Endou H,Burckhardt G,Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition., Am J Physiol Renal Physiol, 287, F124-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kojima R,Sekine T,Kawachi M,Cha SH,Suzuki Y,Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney., J Am Soc Nephrol, 13, 848-57. [PubMed] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kojima R,Sekine T,Kawachi M,Cha SH,Suzuki Y,Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney., J Am Soc Nephrol, 13, 848-57. [PubMed] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
S22A8_RAT (SLC22A8)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kojima R,Sekine T,Kawachi M,Cha SH,Suzuki Y,Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney., J Am Soc Nephrol, 13, 848-57. [PubMed] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Cytoplasmic |
| 18 | 37 | Membrane |
| 38 | 123 | Extracellular |
| 124 | 143 | Membrane |
| 144 | 150 | Cytoplasmic |
| 151 | 171 | Membrane |
| 172 | 177 | Extracellular |
| 178 | 199 | Membrane |
| 200 | 209 | Cytoplasmic |
| 210 | 230 | Membrane |
| 231 | 236 | Extracellular |
| 237 | 256 | Membrane |
| 257 | 325 | Cytoplasmic |
| 326 | 346 | Membrane |
| 347 | 356 | Extracellular |
| 357 | 377 | Membrane |
| 378 | 384 | Cytoplasmic |
| 385 | 405 | Membrane |
| 406 | 412 | Extracellular |
| 413 | 433 | Membrane |
| 434 | 443 | Cytoplasmic |
| 444 | 464 | Membrane |
| 465 | 471 | Extracellular |
| 472 | 492 | Membrane |
| 493 | 536 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 4 | 36703160 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |