Gene name

SLC22A5 (Octn2)

Experiment(s)

For this entry:
S22A5_HUMAN (SLC22A5)
Species Homo sapiens
Localization Apical plasma membrane
Reference Garrett Q,Xu S,Simmons PA,Vehige J,Flanagan JL,Willcox MD (2008) Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium., Invest Ophthalmol Vis Sci, 49, 4844-9.
[PubMed] [DOI]
Evidence level Membrane preparation
Organ Cornea
Cell HCLE cells (epithelial cells)
Notes
S22A5_HUMAN (SLC22A5)
Species Homo sapiens
Localization Apical plasma membrane
Reference Masuda S,Terada T,Yonezawa A,Tanihara Y,Kishimoto K,Katsura T,Ogawa O,Inui K (2006) Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2., J Am Soc Nephrol, 17, 2127-35.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes
S22A5_HUMAN (SLC22A5)
Species Homo sapiens
Localization Apical plasma membrane
Reference Horvath G,Schmid N,Fragoso MA,Schmid A,Conner GE,Salathe M,Wanner A (2007) Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway., Am J Respir Cell Mol Biol, 36, 53-60.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Lung
Cell Airway epithel cells
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 19 Cytoplasmic
20 39 Membrane
40 143 Extracellular
144 163 Membrane
164 170 Cytoplasmic
171 190 Membrane
191 195 Extracellular
196 217 Membrane
218 228 Cytoplasmic
229 250 Membrane
251 257 Extracellular
258 277 Membrane
278 342 Cytoplasmic
343 362 Membrane
363 371 Extracellular
372 393 Membrane
394 400 Cytoplasmic
401 420 Membrane
421 427 Extracellular
428 449 Membrane
450 460 Cytoplasmic
461 482 Membrane
483 489 Extracellular
490 509 Membrane
510 557 Cytoplasmic
Phosphorylation
Glycosylation

Family and domain data

Database Domain/Family name
InterPro MFS_dom
InterPro MFS_sugar_transport-like
InterPro MFS_trans_sf
InterPro Orgcat_transp/SVOP
InterPro Sugar_transporter_CS
Pfam Sugar_tr

Interactions

With (links to EBI) #Exp PubMed links
KRT34_HUMAN 3 32296183
MTUS2_HUMAN 3 32296183
K1C27_HUMAN 3 32296183
NT2NC_HUMAN 3 32296183
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

By using PolarProtDb you accept the Privacy Notice in compliance with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Read the Privacy Notice