Gene name
SLC22A1 (OCT1,Lx1)
Experiment(s)
For this entry:
S22A1_HUMAN (SLC22A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nies AT,Herrmann E,Brom M,Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol, 376, 449-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A1_HUMAN (SLC22A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nies AT,Herrmann E,Brom M,Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol, 376, 449-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
S22A1_HUMAN (SLC22A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nies AT,Herrmann E,Brom M,Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol, 376, 449-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
S22A1_HUMAN (SLC22A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nies AT,Koepsell H,Winter S,Burk O,Klein K,Kerb R,Zanger UM,Keppler D,Schwab M,Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver., Hepatology, 50, 1227-40. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 41 | Membrane |
| 42 | 149 | Extracellular |
| 150 | 170 | Membrane |
| 171 | 177 | Cytoplasmic |
| 178 | 197 | Membrane |
| 198 | 204 | Extracellular |
| 205 | 225 | Membrane |
| 226 | 235 | Cytoplasmic |
| 236 | 255 | Membrane |
| 256 | 262 | Extracellular |
| 263 | 282 | Membrane |
| 283 | 346 | Cytoplasmic |
| 347 | 366 | Membrane |
| 367 | 376 | Extracellular |
| 377 | 397 | Membrane |
| 398 | 404 | Cytoplasmic |
| 405 | 424 | Membrane |
| 425 | 431 | Extracellular |
| 432 | 452 | Membrane |
| 453 | 464 | Cytoplasmic |
| 465 | 485 | Membrane |
| 486 | 492 | Extracellular |
| 493 | 513 | Membrane |
| 514 | 554 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 71 | N-GlycoSiteAtlas | 24495048 | |
| 96 | N-GlycoSiteAtlas | 24495048 | |
| 112 | N-GlycoSiteAtlas | 24495048 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CERS2_HUMAN | 3 | 21988832 , 11543633 |
| SMIM3_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.