Gene name
SLC8A1 (Ncx,NCX1,CNC,ECO:0000303|PubMed:23376057})
Experiment(s)
For this entry:
NAC1_MOUSE (SLC8A1)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gotoh Y,Kita S,Fujii M,Tagashira H,Horie I,Arai Y,Uchida S,Iwamoto T (2015) Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria., Biochem Biophys Res Commun, 456, 670-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 33 | Signal peptide |
| 34 | 74 | Extracellular |
| 75 | 93 | Membrane |
| 94 | 166 | Cytoplasmic |
| 167 | 187 | Membrane |
| 188 | 199 | Extracellular |
| 200 | 221 | Membrane |
| 222 | 231 | Cytoplasmic |
| 232 | 249 | Membrane |
| 250 | 797 | Extracellular |
| 798 | 816 | Membrane |
| 817 | 830 | Cytoplasmic |
| 831 | 848 | Membrane |
| 849 | 871 | Extracellular |
| 872 | 889 | Membrane |
| 890 | 902 | Cytoplasmic |
| 903 | 923 | Membrane |
| 924 | 942 | Extracellular |
| 943 | 961 | Membrane |
| 962 | 970 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CalX-like_sf |
| InterPro | Calx_beta |
| InterPro | DnaJ_domain |
| InterPro | Na_Ca_Ex |
| InterPro | Na_Ca_Ex_C-exten |
| InterPro | NaCa_exhngr1 |
| InterPro | NaCa_Exmemb |
| Pfam | Calx-beta |
| Pfam | Na_Ca_ex |
| Pfam | Na_Ca_ex_C |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ZFP42_MOUSE | 3 | 17093407 |
| NR0B1_MOUSE | 2 | 17093407 |
| NANOG_MOUSE | 9 | 17093407 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.