Gene name

MUC1 (PUM)

Experiment(s)

For this entry:
MUC1_HUMAN (MUC1)
Species Homo sapiens
Localization Apical plasma membrane
Reference Kinlough CL,Poland PA,Gendler SJ,Mattila PE,Mo D,Weisz OA,Hughey RP (2011) Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal., J Biol Chem, 286, 39072-81.
[PubMed] [DOI]
Evidence level Antibody staining + sub-protein manipulation
Organ Kidney
Cell MDCK cells (distal tubule)
Notes The O-glycans were found to be critical for apical targeting
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 23 Signal peptide
24 1159 Extracellular
1160 1181 Membrane
1182 1255 Cytoplasmic
Phosphorylation
Glycosylation
Position Site resource Glycan resource PubMed link(s)
28 O-GlycoProteomDB
29 O-GlycoProteomDB
30 O-GlycoProteomDB
37 O-GlycoProteomDB
38 O-GlycoProteomDB
40 O-GlycoProteomDB
47 O-GlycoProteomDB
48 O-GlycoProteomDB
49 O-GlycoProteomDB
55 O-GlycoProteomDB
58 O-GlycoProteomDB
59 O-GlycoProteomDB
84 O-GlycoProteomDB
88 O-GlycoProteomDB
90 O-GlycoProteomDB
93 O-GlycoProteomDB
99 O-GlycoProteomDB
100 O-GlycoProteomDB
104 O-GlycoProteomDB
110 O-GlycoProteomDB
111 O-GlycoProteomDB
112 O-GlycoProteomDB
130 dbPTM 7744025 , 9363430 , 9597769 , 9312074
131 dbPTM 7744025 , 9363430 , 9597769 , 8206912 , 9312074
131 OGlycoBase 94266797
131 UniProtKB 7744025 , 9597769
139 dbPTM 7744025 , 9363430 , 9597769 , 8206912 , 9312074
139 OGlycoBase 94266797
139 UniProtKB 7744025 , 9597769
140 dbPTM 9312074
144 dbPTM 9312074
151 dbPTM 8206912
151 OGlycoBase 94266797
151 O-GlycoProteomDB
159 dbPTM 8206912
159 OGlycoBase 94266797
159 O-GlycoProteomDB
171 dbPTM 8206912
171 OGlycoBase 94266797
179 dbPTM 8206912
179 OGlycoBase 94266797
191 dbPTM 8206912
191 OGlycoBase 94266797
199 dbPTM 8206912
199 OGlycoBase 94266797
211 dbPTM 8206912
211 OGlycoBase 94266797
219 dbPTM 8206912
219 OGlycoBase 94266797
231 dbPTM 8206912
231 OGlycoBase 94266797
239 dbPTM 8206912
239 OGlycoBase 94266797
251 dbPTM 8206912
251 OGlycoBase 94266797
259 dbPTM 8206912
259 OGlycoBase 94266797
271 dbPTM 8206912
271 OGlycoBase 94266797
279 dbPTM 8206912
279 OGlycoBase 94266797
291 dbPTM 8206912
291 OGlycoBase 94266797
299 dbPTM 8206912
299 OGlycoBase 94266797
311 dbPTM 8206912
311 OGlycoBase 94266797
319 dbPTM 8206912
319 OGlycoBase 94266797
331 dbPTM 8206912
331 OGlycoBase 94266797
339 dbPTM 8206912
339 OGlycoBase 94266797
351 dbPTM 8206912
351 OGlycoBase 94266797
359 dbPTM 8206912
359 OGlycoBase 94266797
371 dbPTM 8206912
371 OGlycoBase 94266797
379 dbPTM 8206912
379 OGlycoBase 94266797
391 dbPTM 8206912
391 OGlycoBase 94266797
399 dbPTM 8206912
399 OGlycoBase 94266797
411 dbPTM 8206912
411 OGlycoBase 94266797
419 dbPTM 8206912
419 OGlycoBase 94266797
431 dbPTM 8206912
431 OGlycoBase 94266797
439 dbPTM 8206912
439 OGlycoBase 94266797
451 dbPTM 8206912
451 OGlycoBase 94266797
459 dbPTM 8206912
459 OGlycoBase 94266797
471 dbPTM 8206912
471 OGlycoBase 94266797
479 dbPTM 8206912
479 OGlycoBase 94266797
491 dbPTM 8206912
491 OGlycoBase 94266797
499 dbPTM 8206912
499 OGlycoBase 94266797
511 dbPTM 8206912
511 OGlycoBase 94266797
519 dbPTM 8206912
519 OGlycoBase 94266797
531 dbPTM 8206912
531 OGlycoBase 94266797
539 dbPTM 8206912
539 OGlycoBase 94266797
551 dbPTM 8206912
551 OGlycoBase 94266797
559 dbPTM 8206912
559 OGlycoBase 94266797
571 dbPTM 8206912
571 OGlycoBase 94266797
579 dbPTM 8206912
579 OGlycoBase 94266797
591 dbPTM 8206912
591 OGlycoBase 94266797
599 dbPTM 8206912
599 OGlycoBase 94266797
611 dbPTM 8206912
611 OGlycoBase 94266797
619 dbPTM 8206912
619 OGlycoBase 94266797
631 dbPTM 8206912
631 OGlycoBase 94266797
639 dbPTM 8206912
639 OGlycoBase 94266797
651 dbPTM 8206912
651 OGlycoBase 94266797
659 dbPTM 8206912
659 OGlycoBase 94266797
671 dbPTM 8206912
671 OGlycoBase 94266797
679 dbPTM 8206912
679 OGlycoBase 94266797
691 dbPTM 8206912
691 OGlycoBase 94266797
699 dbPTM 8206912
699 OGlycoBase 94266797
711 dbPTM 8206912
711 OGlycoBase 94266797
719 dbPTM 8206912
719 OGlycoBase 94266797
731 dbPTM 8206912
731 OGlycoBase 94266797
739 dbPTM 8206912
739 OGlycoBase 94266797
751 dbPTM 8206912
751 OGlycoBase 94266797
759 dbPTM 8206912
759 OGlycoBase 94266797
771 dbPTM 8206912
771 OGlycoBase 94266797
779 dbPTM 8206912
779 OGlycoBase 94266797
791 dbPTM 8206912
791 OGlycoBase 94266797
799 dbPTM 8206912
799 OGlycoBase 94266797
811 dbPTM 8206912
811 OGlycoBase 94266797
819 dbPTM 8206912
819 OGlycoBase 94266797
831 dbPTM 8206912
831 OGlycoBase 94266797
839 dbPTM 8206912
839 OGlycoBase 94266797
851 dbPTM 8206912
851 OGlycoBase 94266797
859 dbPTM 8206912
859 OGlycoBase 94266797
871 dbPTM 8206912
871 OGlycoBase 94266797
879 dbPTM 8206912
879 OGlycoBase 94266797
891 dbPTM 8206912
891 OGlycoBase 94266797
899 dbPTM 8206912
899 OGlycoBase 94266797
911 UniCarbKB WURCS=2.0/1,2,1/[uxxxxh_2*NCC/3=O]/1-1/a?|b?}-{a?|b? 30459171
911 UniCarbKB WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30459171
911 dbPTM 8206912
911 OGlycoBase 94266797
919 UniCarbKB WURCS=2.0/1,2,1/[uxxxxh_2*NCC/3=O]/1-1/a?|b?}-{a?|b? 30459171
919 UniCarbKB WURCS=2.0/1,1,0/[uxxxxh_2*NCC/3=O]/1/ 30459171
919 UniCarbKB WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30459171
919 UniCarbKB WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?|b?|c?|d?}-{a?|b?|c?|d?_a?|b?|c?|d?}-{a?|b?|c?|d?_a?|b?|c?|d?}-{a?|b?|c?|d? 30459171
919 UniCarbKB WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?|b?|c?}-{a?|b?|c?_a?|b?|c?}-{a?|b?|c? 30459171
919 dbPTM 8206912
919 OGlycoBase 94266797
924 UniCarbKB WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b? 30459171
930 UniCarbKB WURCS=2.0/1,2,1/[uxxxxh_2*NCC/3=O]/1-1/a?|b?}-{a?|b? 30459171
930 UniCarbKB WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?|b?|c?|d?}-{a?|b?|c?|d?_a?|b?|c?|d?}-{a?|b?|c?|d?_a?|b?|c?|d?}-{a?|b?|c?|d? 30459171
931 dbPTM 8206912
931 OGlycoBase 94266797
939 dbPTM 8206912
939 OGlycoBase 94266797
982 O-GlycoProteomDB
983 O-GlycoProteomDB
984 O-GlycoProteomDB
987 O-GlycoProteomDB
989 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
989 dbPTM 55826627
989 O-GlycoProteomDB
990 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
990 dbPTM 55826631
990 O-GlycoProteomDB
993 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
993 dbPTM 55826637
993 O-GlycoProteomDB
996 O-GlycoProteomDB
999 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
999 dbPTM 55826643
999 O-GlycoProteomDB
1001 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1001 dbPTM 55826647
1001 O-GlycoProteomDB
1003 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1003 dbPTM 55826651
1003 O-GlycoProteomDB
1004 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1004 dbPTM 55826657
1004 O-GlycoProteomDB
1007 O-GlycoProteomDB
1009 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1009 dbPTM 55826661
1009 O-GlycoProteomDB
1010 PhosphoSitePlus WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/
1010 dbPTM 55826667
1031 O-GlycoProteomDB
1033 O-GlycoProteomDB
1055 Glyconnect WURCS=2.0/4,11,10/[Aad21122h-2x_2-6_5*NCC/3=O][axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-3-3-3-4-4-4-4-4-4/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k? 29741879
1055 Glyconnect WURCS=2.0/3,11,10/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-3-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k? 29741879
1055 Glyconnect WURCS=2.0/3,12,11/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-1-2-2-2-3-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l? 29741879
1055 Glyconnect WURCS=2.0/3,12,11/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-1-2-2-2-2-2-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?|l? 29741879
1055 Glyconnect WURCS=2.0/3,11,10/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-1-2-2-2-3-3-3-3-3/a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?_a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?|j?|k? 29741879
1055 N-GlycoSiteAtlas

Family and domain data

Database Domain/Family name
InterPro Mucin-1
InterPro SEA_dom
InterPro SEA_dom_sf
Pfam SEA

Interactions

With (links to EBI) #Exp PubMed links
EGFR_HUMAN 3 24658140 , 31980649
U2AF2_HUMAN 2 22905162
AQP3_HUMAN 3 32296183
AQP1_HUMAN 3 32296183
AQP2_HUMAN 3 32296183
MAL2_HUMAN 3 32296183
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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