Gene name
Lrp2
Experiment(s)
For this entry:
LRP2_RAT (Lrp2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ljubojevic M,Herak-Kramberger CM,Hagos Y,Bahn A,Endou H,Burckhardt G,Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition., Am J Physiol Renal Physiol, 287, F124-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Signal peptide |
| 26 | 4425 | Extracellular |
| 4426 | 4447 | Membrane |
| 4448 | 4660 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 6-blade_b-propeller_TolB-like |
| InterPro | cEGF |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | LDL_receptor-like_sf |
| InterPro | LDLR_class-A_CS |
| InterPro | LDLR_classB_rpt |
| InterPro | LDrepeatLR_classA_rpt |
| Pfam | cEGF |
| Pfam | EGF_CA |
| Pfam | Ldl_recept_a |
| Pfam | Ldl_recept_b |