Gene name
Kcnq1 (KCNA8,Kcna9,Kvlqt1)
Experiment(s)
For this entry:
KCNQ1_HUMAN (Kcnq1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Andersen MN,Olesen SP,Rasmussen HB (2011) Kv7.1 surface expression is regulated by epithelial cell polarization., Am J Physiol Cell Physiol, 300, C814-24. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 122 | Cytoplasmic |
| 123 | 143 | Membrane |
| 144 | 153 | Extracellular |
| 154 | 173 | Membrane |
| 174 | 197 | Cytoplasmic |
| 198 | 217 | Membrane |
| 218 | 261 | Extracellular |
| 262 | 282 | Membrane |
| 283 | 295 | Cytoplasmic |
| 296 | 315 | Membrane |
| 316 | 327 | Extracellular |
| 328 | 353 | Membrane |
| 354 | 676 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ion_trans_dom |
| InterPro | K_chnl_volt-dep_KCNQ |
| InterPro | K_chnl_volt-dep_KCNQ_C |
| InterPro | K_chnl_volt-dep_KCQN1 |
| InterPro | VG_K_chnl |
| Pfam | Ion_trans |
| Pfam | KCNQ_channel |