Gene name
Kcnj10
Experiment(s)
For this entry:
KCJ10_HUMAN (Kcnj10)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Tanemoto M,Abe T,Uchida S,Kawahara K (2014) Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome., FEBS Lett, 588, 899-905. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 65 | Cytoplasmic |
| 66 | 91 | Membrane |
| 92 | 115 | Extracellular |
| 116 | 131 | Re-entrant loop |
| 132 | 141 | Extracellular |
| 142 | 166 | Membrane |
| 167 | 379 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ig_E-set |
| InterPro | IRK_C |
| InterPro | K_chnl_inward-rec_Kir |
| InterPro | K_chnl_inward-rec_Kir1.2 |
| InterPro | K_chnl_inward-rec_Kir_cyto |
| InterPro | Kir_TM |
| Pfam | IRK |
| Pfam | IRK_C |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| SIAH1_HUMAN | 3 | 25416956 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.