Gene name
ATP2B1 (PMCA1)
Experiment(s)
For this entry:
J9P4S0_CANLF (ATP2B1)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 108 | Cytoplasmic |
| 109 | 126 | Membrane |
| 127 | 153 | Extracellular |
| 154 | 172 | Membrane |
| 173 | 375 | Cytoplasmic |
| 376 | 394 | Membrane |
| 395 | 418 | Extracellular |
| 419 | 439 | Membrane |
| 440 | 855 | Cytoplasmic |
| 856 | 876 | Membrane |
| 877 | 884 | Extracellular |
| 885 | 903 | Membrane |
| 904 | 931 | Cytoplasmic |
| 932 | 949 | Membrane |
| 950 | 970 | Extracellular |
| 971 | 988 | Membrane |
| 989 | 1006 | Cytoplasmic |
| 1007 | 1024 | Membrane |
| 1025 | 1040 | Extracellular |
| 1041 | 1061 | Membrane |
| 1062 | 1220 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATP2B1 |
| InterPro | ATP_Ca_trans_C |
| InterPro | ATPase_P-typ_cation-transptr_C |
| InterPro | ATPase_P-typ_cation-transptr_N |
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | HAD_sf |
| InterPro | P-type_ATPase_IIB |
| InterPro | P_typ_ATPase |
| Pfam | ATP_Ca_trans_C |
| Pfam | Cation_ATPase_C |
| Pfam | Cation_ATPase_N |