Gene name
Ereg
Experiment(s)
For this entry:
EREG_HUMAN (Ereg)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Singh B,Bogatcheva G,Washington MK,Coffey RJ (2013) Transformation of polarized epithelial cells by apical mistrafficking of epiregulin., Proc Natl Acad Sci U S A, 110, 8960-5. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Sorting depended on a Tyr-based signal |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 29 | Signal peptide |
| 30 | 118 | Extracellular |
| 119 | 140 | Membrane |
| 141 | 169 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Phosphorylation
| Position | Resource |
|---|---|
| 144 | 25290882 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | EGF-like_dom |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| M4A13_HUMAN | 3 | 32296183 |
| EGFR_HUMAN | 3 | 28988771 |
| NINJ2_HUMAN | 3 | 32296183 |
| OLFM4_HUMAN | 3 | 32296183 |
| CXCL9_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.