Gene name
ENPP3 (PDNP3,LOC100073089)
Experiment(s)
For this entry:
ENPP3_HUMAN (ENPP3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Yano Y,Hayashi Y,Sano K,Nagano H,Nakaji M,Seo Y,Ninomiya T,Yoon S,Yokozaki H,Kasuga M (2004) Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases., Cancer Lett, 207, 139-47. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 22 | Cytoplasmic |
| 23 | 43 | Membrane |
| 44 | 875 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 236 | UniProtKB | 29717535 | |
| 279 | N-GlycoSiteAtlas | 23586699 | |
| 279 | UniProtKB | 29717535 | |
| 290 | N-GlycoSiteAtlas | 23586699 | |
| 290 | PolarProtDb | 31844046 | |
| 290 | UniProtKB | 29717535 | |
| 426 | N-GlycoSiteAtlas | 24495048 | |
| 426 | UniProtKB | 29717535 | |
| 533 | UniProtKB | 29717535 | |
| 533 | N-GlycoSiteAtlas | 24191733 , 24190977 | |
| 582 | UniProtKB | 29717535 | |
| 594 | UniProtKB | 29717535 | |
| 687 | N-GlycoSiteAtlas | 24495048 | |
| 687 | PolarProtDb | 31844046 | |
| 687 | UniProtKB | 29717535 | |
| 699 | N-GlycoSiteAtlas | 24190977 | |
| 699 | PolarProtDb | 31844046 | |
| 699 | UniProtKB | 29717535 | |
| 789 | UniProtKB | 29717535 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Alkaline_phosphatase_core_sf |
| InterPro | DNA/RNA_non-sp_Endonuclease |
| InterPro | Extracellular_endonuc_su_A |
| InterPro | Phosphodiest/P_Trfase |
| InterPro | Somatomedin_B-like_dom_sf |
| InterPro | Somatomedin_B_dom |
| Pfam | Endonuclease_NS |
| Pfam | Phosphodiest |
| Pfam | Somatomedin_B |