Gene name

ITGA2 (CD49B)

Experiment(s)

For this entry:
E2REA9_CANLF (ITGA2)
Species Canis lupus familiaris
Localization Basolateral plasma membrane
Reference Tan B,Yatim SMJM,Peng S,Gunaratne J,Hunziker W,Ludwig A (2020) The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions., Curr Biol, 30, 2791-2804.e6.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Kidney
Cell MDCK cells (distal tubule)
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 28 Signal peptide
29 1129 Extracellular
1130 1151 Membrane
1152 1179 Cytoplasmic

Family and domain data

Database Domain/Family name
InterPro FG-GAP
InterPro Int_alpha_beta-p
InterPro Integrin_alpha
InterPro Integrin_alpha-2
InterPro Integrin_alpha_C_CS
InterPro Integrin_alpha_N
InterPro Integrin_dom_sf
InterPro VWF_A
InterPro vWFA_dom_sf
Pfam FG-GAP
Pfam Integrin_alpha2
Pfam VWA

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