Gene name

EPHA1

Experiment(s)

For this entry:
E2R6A6_CANLF (EPHA1)
Species Canis lupus familiaris
Localization Basolateral plasma membrane
Reference Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Kidney
Cell MDCK cells (distal tubule)
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 25 Signal peptide
26 553 Extracellular
554 569 Membrane
570 976 Cytoplasmic

Family and domain data

Database Domain/Family name
InterPro Eph_TM
InterPro EphA1_rcpt_lig-bd
InterPro Ephrin_rcpt_lig-bd_dom
InterPro FN3_dom
InterPro FN3_sf
InterPro Galactose-bd-like_sf
InterPro Ig-like_fold
InterPro Kinase-like_dom_sf
InterPro Prot_kinase_dom
InterPro Protein_kinase_ATP_BS
InterPro SAM
InterPro SAM/pointed_sf
InterPro Ser-Thr/Tyr_kinase_cat_dom
InterPro Tyr-kin_ephrin_A/B_rcpt-like
InterPro Tyr_kinase_AS
InterPro Tyr_kinase_cat_dom
InterPro Tyr_kinase_ephrin_rcpt
InterPro Tyr_kinase_rcpt_V_CS
Pfam EphA2_TM
Pfam Ephrin_lbd
Pfam fn3
Pfam PK_Tyr_Ser-Thr
Pfam SAM_1

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