Gene name
Lrp1 (A2MR,APR)
Experiment(s)
For this entry:
E2R4Q1_CANLF (Lrp1)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Donoso M,Cancino J,Lee J,van Kerkhof P,Retamal C,Bu G,Gonzalez A,Cáceres A,Marzolo MP (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways., Mol Biol Cell, 20, 481-97. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Endogenous protein |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Signal peptide |
| 20 | 4422 | Extracellular |
| 4423 | 4443 | Membrane |
| 4444 | 4544 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 6-blade_b-propeller_TolB-like |
| InterPro | cEGF |
| InterPro | DUF5050 |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | LDL_receptor-like_sf |
| InterPro | LDLR_class-A_CS |
| InterPro | LDLR_classB_rpt |
| InterPro | LDrepeatLR_classA_rpt |
| Pfam | cEGF |
| Pfam | DUF5050 |
| Pfam | EGF_CA |
| Pfam | Ldl_recept_a |
| Pfam | Ldl_recept_b |