Gene name

GPNMB (Dchil,HGFIN,NMB)

Experiment(s)

For this entry:
E2QUR6_CANLF (GPNMB)
Species Canis lupus familiaris
Localization Apical plasma membrane
Reference Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Kidney
Cell MDCK cells (distal tubule)
Notes Cutoff: at least 80% apical
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 23 Signal peptide
24 482 Extracellular
483 502 Membrane
503 554 Cytoplasmic

Family and domain data

Database Domain/Family name
InterPro Ig-like_fold
InterPro PKD/Chitinase_dom
InterPro PKD_dom
InterPro PKD_dom_sf
Pfam PKD

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