Gene name
Dsc3 (CDHF3,DSC4,Dsc3_predicted)
Experiment(s)
For this entry:
DSC3_HUMAN (Dsc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 32 | Signal peptide |
| 33 | 690 | Extracellular |
| 691 | 713 | Membrane |
| 714 | 896 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 81 | 25289872 |
| 93 | 23100811 |
| 95 | 23100823 |
| 99 | 23100814 |
| 278 | 34348909 |
| 282 | 23100826 |
| 283 | 23100805 |
| 288 | 23100817 |
| 407 | 18009056 |
| 408 | 18009059 |
| 412 | 18009062 |
| 418 | 18009065 |
| 425 | 18009068 |
| 636 | 23100808 |
| 637 | 23100829 |
| 788 | 18260548 |
| 800 | 27447725 |
| 803 | 34500918 |
| 816 | 465146 |
| 817 | 12432469 |
| 818 | 465147 |
| 819 | 15229853 |
| 823 | 18009071 |
| 848 | 15409517 |
| 868 | 7101373 |
| 894 | 23100820 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 95 | O-GlycoProteomDB | ||
| 110 | O-GlycoProteomDB | ||
| 166 | N-GlycoSiteAtlas | 26571101 | |
| 392 | N-GlycoSiteAtlas | 21142092 , 26256267 | |
| 392 | PolarProtDb | 31844046 | |
| 546 | N-GlycoSiteAtlas | 21142092 | |
| 546 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cadherin-like_dom |
| InterPro | Cadherin-like_sf |
| InterPro | Cadherin_CS |
| InterPro | Cadherin_cytoplasmic-dom |
| InterPro | Cadherin_pro_dom |
| InterPro | Catenin_binding_dom_sf |
| InterPro | Desmosomal_cadherin |
| Pfam | Cadherin |
| Pfam | Cadherin_C |
| Pfam | Cadherin_pro |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| LAMP1_HUMAN | 2 | 29568061 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.