Gene name
Comt (Comt1)
Experiment(s)
For this entry:
COMT_HUMAN (Comt)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Pshezhetsky AV,Fedjaev M,Ashmarina L,Mazur A,Budman L,Sinnett D,Labuda D,Beaulieu JF,Ménard D,Nifant'ev I,Levy E (2007) Subcellular proteomics of cell differentiation: quantitative analysis of the plasma membrane proteome of Caco-2 cells., Proteomics, 7, 2201-15. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | Cutoff: at least 4-fold enrichment (A/total) at any repetition |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 6 | Extracellular |
| 7 | 26 | Membrane |
| 27 | 271 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Catechol_O-MeTrfase_euk |
| InterPro | SAM-dependent_MTases |
| InterPro | SAM_O-MeTrfase |
| Pfam | Methyltransf_3 |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.