Gene name

CD63 (MLA1,TSPAN30)

Experiment(s)

For this entry:
CD63_HUMAN (CD63)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Schulze U,Brast S,Grabner A,Albiker C,Snieder B,Holle S,Schlatter E,Schröter R,Pavenstädt H,Herrmann E,Lambert C,Spoden GA,Florin L,Saftig P,Ciarimboli G (2017) Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules., FASEB J, 31, 1421-1433.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 11 Cytoplasmic
12 35 Membrane
36 51 Extracellular
52 73 Membrane
74 82 Cytoplasmic
83 106 Membrane
107 204 Extracellular
205 228 Membrane
229 238 Cytoplasmic
Phosphorylation
Position Resource
159 18909320
Glycosylation

Family and domain data

Database Domain/Family name
InterPro CD63_LEL
InterPro Tetraspanin
InterPro Tetraspanin/Peripherin
InterPro Tetraspanin_CS
InterPro Tetraspanin_EC2_sf
Pfam Tetraspanin

Interactions

With (links to EBI) #Exp PubMed links
TIMP1_HUMAN 3 28030805
ENV_HV1H2 4 25312088
TMM80_HUMAN 3 32296183
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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