Gene name
BTC
Experiment(s)
For this entry:
BTC_HUMAN (BTC)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Singh B,Bogatcheva G,Starchenko A,Sinnaeve J,Lapierre LA,Williams JA,Goldenring JR,Coffey RJ (2015) Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin., J Cell Sci, 128, 3444-55. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A monoleucine motif was identified as the basolateral signal |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 31 | Signal peptide |
| 32 | 118 | Extracellular |
| 119 | 141 | Membrane |
| 142 | 178 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 156 | 162 | Basolateral plasma membrane | Monoleucine |
Singh B,Bogatcheva G,Starchenko A,Sinnaeve J,Lapierre LA,Williams JA,Goldenring JR,Coffey RJ (2015) Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin., J Cell Sci, 128, 3444-55. [PubMed][DOI] |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 56 | O-GlycoProteomDB | ||
| 57 | O-GlycoProteomDB | ||
| 58 | O-GlycoProteomDB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | EGF-like_dom |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| GMPPA_HUMAN | 6 | 25416956 , 26871637 |
| K1H1_HUMAN | 6 | 25416956 , 32296183 |
| SGTA_HUMAN | 6 | 25910212 , 32296183 |
| KPRP_HUMAN | 3 | 32296183 |
| SGTB_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.