Gene name

AQP5

Experiment(s)

For this entry:
AQP5_MOUSE (AQP5)
Species Mus musculus
Localization Apical plasma membrane
Reference Pani B,Liu X,Bollimuntha S,Cheng KT,Niesman IR,Zheng C,Achen VR,Patel HH,Ambudkar IS,Singh BB (2013) Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1., J Cell Sci, 126, 667-75.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Salivary gland
Cell Acinar cells
Notes Cytoplasmic-to-apical translocation is stimulus-dependent
AQP5_MOUSE (AQP5)
Species Mus musculus
Localization Apical plasma membrane
Reference Inoue R,Sohara E,Rai T,Satoh T,Yokozeki H,Sasaki S,Uchida S (2013) Immunolocalization and translocation of aquaporin-5 water channel in sweat glands., J Dermatol Sci, 70, 26-33.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Sweat glands
Cell Secretory cells
Notes Apical localization in sweat glands appears to be stimulus-dependent
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 13 Cytoplasmic
14 31 Membrane
32 43 Extracellular
44 61 Membrane
62 64 Cytoplasmic
65 78 Re-entrant loop
79 87 Cytoplasmic
88 105 Membrane
106 131 Extracellular
132 149 Membrane
150 159 Cytoplasmic
160 177 Membrane
178 180 Extracellular
181 194 Re-entrant loop
195 203 Extracellular
204 221 Membrane
222 265 Cytoplasmic
Phosphorylation
Position Resource
259 460666

Family and domain data

Database Domain/Family name
InterPro Aquaporin-like
InterPro Aquaporin_5
InterPro Aquaporin_transptr
InterPro MIP
InterPro MIP_CS
Pfam MIP

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