Gene name
AQP4
Experiment(s)
For this entry:
AQP4_MOUSE (AQP4)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Wang KS,Komar AR,Ma T,Filiz F,McLeroy J,Hoda K,Verkman AS,Bastidas JA (2000) Gastric acid secretion in aquaporin-4 knockout mice., Am J Physiol Gastrointest Liver Physiol, 279, G448-53. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Stomach |
| Cell | Parietal cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 37 | Cytoplasmic |
| 38 | 55 | Membrane |
| 56 | 71 | Extracellular |
| 72 | 89 | Membrane |
| 90 | 92 | Cytoplasmic |
| 93 | 106 | Re-entrant loop |
| 107 | 115 | Cytoplasmic |
| 116 | 133 | Membrane |
| 134 | 159 | Extracellular |
| 160 | 177 | Membrane |
| 178 | 187 | Cytoplasmic |
| 188 | 205 | Membrane |
| 206 | 209 | Extracellular |
| 210 | 223 | Re-entrant loop |
| 224 | 230 | Extracellular |
| 231 | 248 | Membrane |
| 249 | 323 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aquaporin-like |
| InterPro | Aquaporin_transptr |
| InterPro | MIP |
| InterPro | MIP_CS |
| Pfam | MIP |