Gene name
ABCG8
Experiment(s)
For this entry:
ABCG8_MOUSE (ABCG8)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Graf GA,Yu L,Li WP,Gerard R,Tuma PL,Cohen JC,Hobbs HH (2003) ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion., J Biol Chem, 278, 48275-82. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 415 | Cytoplasmic |
| 416 | 436 | Membrane |
| 437 | 449 | Extracellular |
| 450 | 471 | Membrane |
| 472 | 492 | Cytoplasmic |
| 493 | 514 | Membrane |
| 515 | 527 | Extracellular |
| 528 | 549 | Membrane |
| 550 | 557 | Cytoplasmic |
| 558 | 578 | Membrane |
| 579 | 640 | Extracellular |
| 641 | 662 | Membrane |
| 663 | 673 | Cytoplasmic |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ABC_2_trans |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | P-loop_NTPase |
| Pfam | ABC2_membrane |
| Pfam | ABC_tran |