Gene name

ABCG2 (Abcp,BCRP,Bcrp1,MXR,BMDP)

Experiment(s)

For this entry:
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Zhang W,Mojsilovic-Petrovic J,Andrade MF,Zhang H,Ball M,Stanimirovic DB (2003) The expression and functional characterization of ABCG2 in brain endothelial cells and vessels., FASEB J, 17, 2085-7.
[PubMed] [DOI]
Evidence level Functional assay
Organ Vessels
Cell Brain capillary endothelial cells
Notes A substrate transporter assay was used
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Maliepaard M,Scheffer GL,Faneyte IF,van Gastelen MA,Pijnenborg AC,Schinkel AH,van De Vijver MJ,Scheper RJ,Schellens JH (2001) Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues., Cancer Res, 61, 3458-64.
[PubMed]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Maliepaard M,Scheffer GL,Faneyte IF,van Gastelen MA,Pijnenborg AC,Schinkel AH,van De Vijver MJ,Scheper RJ,Schellens JH (2001) Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues., Cancer Res, 61, 3458-64.
[PubMed]
Evidence level Antibody staining
Organ Small intestine
Cell Enterocytes
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Maliepaard M,Scheffer GL,Faneyte IF,van Gastelen MA,Pijnenborg AC,Schinkel AH,van De Vijver MJ,Scheper RJ,Schellens JH (2001) Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues., Cancer Res, 61, 3458-64.
[PubMed]
Evidence level Antibody staining
Organ Large intestine
Cell Enterocytes
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Maliepaard M,Scheffer GL,Faneyte IF,van Gastelen MA,Pijnenborg AC,Schinkel AH,van De Vijver MJ,Scheper RJ,Schellens JH (2001) Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues., Cancer Res, 61, 3458-64.
[PubMed]
Evidence level Antibody staining
Organ Liver
Cell Hepatocytes
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Cooray HC,Blackmore CG,Maskell L,Barrand MA (2002) Localisation of breast cancer resistance protein in microvessel endothelium of human brain., Neuroreport, 13, 2059-63.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Vessels
Cell Brain capillary endothelial cells
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Takada T,Suzuki H,Sugiyama Y (2005) Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells., Pharm Res, 22, 458-64.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell LLC-PK1 cells (proximal tubule)
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Huls M,Brown CD,Windass AS,Sayer R,van den Heuvel JJ,Heemskerk S,Russel FG,Masereeuw R (2008) The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane., Kidney Int, 73, 220-5.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes Primary kidney cells were also examined in culture
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Uehara I,Kimura T,Tanigaki S,Fukutomi T,Sakai K,Shinohara Y,Ichida K,Iwashita M,Sakurai H (2014) Paracellular route is the major urate transport pathway across the blood-placental barrier., Physiol Rep, 2, .
[PubMed] [DOI]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Kozłowska-Rup D,Czekaj P,Plewka D,Sikora J (2014) Immunolocalization of ABC drug transporters in human placenta from normal and gestational diabetic pregnancies., Ginekol Pol, 85, 410-9.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes
ABCG2_HUMAN (ABCG2)
Species Homo sapiens
Localization Apical plasma membrane
Reference Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier., Cancer Res, 65, 11419-28.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Vessels
Cell Brain capillary endothelial cells
Notes
For ortholog entries:
ABCG2_MOUSE
ABCG2_MOUSE
ABCG2_MOUSE
ABCG2_MOUSE
ABCG2_MOUSE
ABCG2_RAT
ABCG2_PIG

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 393 Cytoplasmic
394 414 Membrane
415 428 Extracellular
429 449 Membrane
450 477 Cytoplasmic
478 498 Membrane
499 505 Extracellular
506 527 Membrane
528 535 Cytoplasmic
536 556 Membrane
557 629 Extracellular
630 650 Membrane
651 655 Cytoplasmic
Phosphorylation
Position Resource
50 25279339
100 18006311
103 18006314
143 23078484
187 3959611
194 9216762
195 3959616
353 36133579
362 1818104
464 34606523
Glycosylation
Position Site resource Glycan resource PubMed link(s)
596 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 28554189
596 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 28554189
596 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 29610494
596 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 30405239
596 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29610494
596 dbPTM 15807535
596 PolarProtDb 31844046
596 UniProtKB 15807535 , 28554189

Family and domain data

Database Domain/Family name
InterPro AAA+_ATPase
InterPro ABC_2_trans
InterPro ABC_transporter-like
InterPro ABCG2
InterPro P-loop_NTPase
Pfam ABC2_membrane
Pfam ABC_tran

Interactions

With (links to EBI) #Exp PubMed links
PIM1_HUMAN 5 18056989
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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